产品
编 号：F757090
分子式：C54H60N14O18S2
分子量：1257.27
分子式：C54H60N14O18S2
分子量：1257.27
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CAS No: 2946600-14-0
产品详情
生物活性：
PSMA-IN-2 is an inhibitor of PSMA with a Ki value of 1.07 nM. PSMA-IN-2 displays favorable in vivo NIR imaging (λEM = 1088 nm, λex = 808 nm), and can be used for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice.
体内研究：
PSMA-IN-2(compound 24) (0.85 mg/kg, i.v., 24 h)is confirmed by NIR-II imaging to bind specifically to PSMA in vivo.Animal Model:22Rv1 xenograft models
Dosage:0.85 mg/kg
Administration:Intravenous injection (i.v.)
Result:Excreted from the blood pool, increasing signal intensity was observed in 22Rv1 xenograft over time as, the background signal became gradually weak, under 808 nm laser irradiation (1100 nm long-pass filter, 400 ms).Inhibition ranged from 38% to 52%, based on semi-quantitative data DCFPyL in tumors.
PSMA-IN-2 is an inhibitor of PSMA with a Ki value of 1.07 nM. PSMA-IN-2 displays favorable in vivo NIR imaging (λEM = 1088 nm, λex = 808 nm), and can be used for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice.
体内研究：
PSMA-IN-2(compound 24) (0.85 mg/kg, i.v., 24 h)is confirmed by NIR-II imaging to bind specifically to PSMA in vivo.Animal Model:22Rv1 xenograft models
Dosage:0.85 mg/kg
Administration:Intravenous injection (i.v.)
Result:Excreted from the blood pool, increasing signal intensity was observed in 22Rv1 xenograft over time as, the background signal became gradually weak, under 808 nm laser irradiation (1100 nm long-pass filter, 400 ms).Inhibition ranged from 38% to 52%, based on semi-quantitative data DCFPyL in tumors.
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