产品
编 号：F757052
分子式：C52H99BFN3O3
分子量：844.17
分子式：C52H99BFN3O3
分子量：844.17
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CAS No: 2939000-43-6
产品详情
生物活性：
Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity.
体内研究：
Diamino lipid DAL4 (DAL4-LNP) loaded with IL-12 mRNA (intratumoral injection) is most potent in inhibiting B16F10 melanoma tumor growth compared to IL-27 or GM-CSF mRNAs in monotherapy.Diamino lipid DAL4 loaded with IL-12 mRNA and IL-27 mRNA (intratumoral injection) shows synergistic effect in suppressing tumor growth without causing systematic toxicity. And also Diamino lipid DAL4 induces robust infiltration of immune effector cells, including IFN-γ and TNF-α producing natural killer cells (NK) and CD8+ T cells into tumors.
体外研究：
Diamino lipid DAL4 (DAL4-LNP) effectively delivers different mRNAs in vitro to tumor cells.
Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity.
体内研究：
Diamino lipid DAL4 (DAL4-LNP) loaded with IL-12 mRNA (intratumoral injection) is most potent in inhibiting B16F10 melanoma tumor growth compared to IL-27 or GM-CSF mRNAs in monotherapy.Diamino lipid DAL4 loaded with IL-12 mRNA and IL-27 mRNA (intratumoral injection) shows synergistic effect in suppressing tumor growth without causing systematic toxicity. And also Diamino lipid DAL4 induces robust infiltration of immune effector cells, including IFN-γ and TNF-α producing natural killer cells (NK) and CD8+ T cells into tumors.
体外研究：
Diamino lipid DAL4 (DAL4-LNP) effectively delivers different mRNAs in vitro to tumor cells.
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