产品
编 号：F757041
分子式：C35H33F3N8O3
分子量：670.68
分子式：C35H33F3N8O3
分子量：670.68
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CAS No: 2937543-72-9
产品详情
生物活性：
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively. Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
Type II TRK?inhibitor 1 (compound 7b) (3.1-800 nM; 2 h) 抑制 TRKA，PLCγ1 和 ERK 的磷酸化。
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively. Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
Type II TRK?inhibitor 1 (compound 7b) (3.1-800 nM; 2 h) 抑制 TRKA，PLCγ1 和 ERK 的磷酸化。
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