产品
编 号：F757030
分子式：C27H37N5O5
分子量：511.61
分子式：C27H37N5O5
分子量：511.61
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结构图
CAS No: 2934738-40-4
产品详情
生物活性：
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
体外研究：
Antileishmanial agent-17 (compound 14b) 抑制叶酸途径，对叶酸的抑制率为 82% 和 91%，对亚叶酸的抑制率为 88% 和 91%，分别为 20 μM 和 100 μM。Antileishmanial agent-17 对非洲绿猴肾细胞 (VERO 细胞) 表现出微弱的细胞毒性，CC50 为 244.3 μM。
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
体外研究：
Antileishmanial agent-17 (compound 14b) 抑制叶酸途径，对叶酸的抑制率为 82% 和 91%，对亚叶酸的抑制率为 88% 和 91%，分别为 20 μM 和 100 μM。Antileishmanial agent-17 对非洲绿猴肾细胞 (VERO 细胞) 表现出微弱的细胞毒性，CC50 为 244.3 μM。
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