产品
编 号：F757018
分子式：C22H18Cl2N2O3S
分子量：461.36
分子式：C22H18Cl2N2O3S
分子量：461.36
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2931509-15-6
产品详情
生物活性：
USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331).
体外研究：
USP28-IN-4 (compound 9p) (12.5 μM，15 μM；3 d) 抑制人结直肠癌细胞 HCT116 (15 μM) 和 Ls174T (12.5 μM) 的集落形成。USP28-IN-4 (20-80 μM；24 小时) 通过泛素-蛋白酶体系统 (UPS) 增强其降解，从而下调 c-Myc 的水平。
USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331).
体外研究：
USP28-IN-4 (compound 9p) (12.5 μM，15 μM；3 d) 抑制人结直肠癌细胞 HCT116 (15 μM) 和 Ls174T (12.5 μM) 的集落形成。USP28-IN-4 (20-80 μM；24 小时) 通过泛素-蛋白酶体系统 (UPS) 增强其降解，从而下调 c-Myc 的水平。
产品资料
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