产品
编 号:F757014
分子式:C20H23ClN2O5
分子量:406.86
产品类型
结构图
CAS No: 2930378-91-7
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产品详情
生物活性:
GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2.
体外研究:
GAK inhibitor 49 (compound 49) hydrochloride shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC50s of 28, 63 and >100μM, respectively.