产品
编 号：F756986
分子式：C26H26ClF3N8O
分子量：558.99
分子式：C26H26ClF3N8O
分子量：558.99
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 2926498-81-7
产品详情
生物活性：
CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.
体内研究：
Animal Model:Homozygous nu/nu mice with SHH-subtype MYCN-expressing medulloblastoma
Dosage:25 mg/kg
Administration:I.p. twice weekly for 3 weeks
Result:Decreased the level of MYCN protein and tumor volume and increases survival.
CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.
体内研究：
Animal Model:Homozygous nu/nu mice with SHH-subtype MYCN-expressing medulloblastoma
Dosage:25 mg/kg
Administration:I.p. twice weekly for 3 weeks
Result:Decreased the level of MYCN protein and tumor volume and increases survival.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备