产品
编 号：F756973
分子式：C27H30N4O4
分子量：474.55
分子式：C27H30N4O4
分子量：474.55
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CAS No: 2925457-33-4
产品详情
生物活性：
BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
体外研究：
BChE/HDAC6-IN-2 (compound 29a) (0.1 μM，1 μM；24 小时) 在 10 μM Aβ(1-42) 处理的 SH-SY5Y 细胞中增加 α-微管蛋白的乙酰化水平，抑制 tau 的磷酸化。BChE/HDAC6-IN-2 (5 μM、10 μM、20 μM) 抑制 SH-SY5Y 细胞中谷氨酸诱导的损伤，显示出神经保护作用。
BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
体外研究：
BChE/HDAC6-IN-2 (compound 29a) (0.1 μM，1 μM；24 小时) 在 10 μM Aβ(1-42) 处理的 SH-SY5Y 细胞中增加 α-微管蛋白的乙酰化水平，抑制 tau 的磷酸化。BChE/HDAC6-IN-2 (5 μM、10 μM、20 μM) 抑制 SH-SY5Y 细胞中谷氨酸诱导的损伤，显示出神经保护作用。
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