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编 号：F756963
分子式：C28H40N4O7
分子量：544.64
分子式：C28H40N4O7
分子量：544.64
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CAS No: 2925302-01-6
产品详情
生物活性：
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.
体内研究：
Koshidacin B (30 mg/kg; i.p.; once daily for 4 d) shows vivo antiplasmodial effects.Animal Model:P. berghei N strain-infected ICR (CD1) mice
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
Result:Suppressed 41% of malaria parasites.
体外研究：
Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC50 values of 0.89 and 0.83 μM, respectively.Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC50 value of 14.7 μM.
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.
体内研究：
Koshidacin B (30 mg/kg; i.p.; once daily for 4 d) shows vivo antiplasmodial effects.Animal Model:P. berghei N strain-infected ICR (CD1) mice
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
Result:Suppressed 41% of malaria parasites.
体外研究：
Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC50 values of 0.89 and 0.83 μM, respectively.Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC50 value of 14.7 μM.
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