产品
编 号：F756962
分子式：C25H21ClFNO
分子量：405.89
分子式：C25H21ClFNO
分子量：405.89
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规格
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CAS No: 2925298-08-2
产品详情
生物活性：
SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research.
体外研究：
SB-1436 (Compound 7av) (1 μM, 20 分钟) 对 AChE， BChE 和 rHuAChE 具有抑制作用，IC50s 分别为 0.176，0.37 和 0.08 μM。SB-1436 (0.78-100 μM, 48 小时) 降低了 J774A.1 细胞和初级星形胶质细胞细胞的生存能力。
SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research.
体外研究：
SB-1436 (Compound 7av) (1 μM, 20 分钟) 对 AChE， BChE 和 rHuAChE 具有抑制作用，IC50s 分别为 0.176，0.37 和 0.08 μM。SB-1436 (0.78-100 μM, 48 小时) 降低了 J774A.1 细胞和初级星形胶质细胞细胞的生存能力。
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