产品
编 号：F756961
分子式：C25H18N2O3
分子量：394.42
分子式：C25H18N2O3
分子量：394.42
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CAS No: 2925288-12-4
产品详情
生物活性：
Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO) and suppresses neuronal apoptotic by inhibiting inflammatory and apoptotic signaling pathways. Flo8 can be used for Parkinson's Disease (PD) research.
体内研究：
Compound Flo8 (15/35 mg/kg，腹腔注射，每天/两周) 能缓解 MPTP 诱导 C57BL/6J 小鼠大脑中的神经炎症并抑制神经凋亡。Animal Model:MPTP C57BL/6J mice model
Dosage:15 mg/kg, 35 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Increased the mRNA expression of CD86, TNF-α, IL-6 and IL-1β but decreased CD206, Arg-1 and IL-10 in brain tissue.Inhibited the expression of MPTP-induced phosphorylation of p38, ERK, JNK and NF-κ B.Reduced dopamine levels in mouse serum in the MPTP group.Increased the protein expression of Caspase3 and BAX but decreased the expression of Bcl2 after MPTP induction in brain tissue.
体外研究：
Compound Flo8 (5 μM, 10 μM, 18 小时) 对 BV2 细胞活力的抑制作用较小。Compound Flo8 (5 μM, 18小时) 对 BV2 细胞中 ROS 的产生具有明显的抑制作用。Compound Flo8 (5 μM, 10 μM, 18小时) 通过减少 BV2 细胞中炎症因子的表达，降低 SH-SY5Y 细胞的凋亡水平。Compound Flo8 (5 μM, 10 μM, 18小时) 抑制 LPS 诱导的小胶质细胞 M1 极化，促进 M2 极化。Compound Flo8 (5 μM, 10 μM, 18小时) 抑制 LPS 诱导的 BV2 细胞中 ERK，p38 和 JNK 磷酸化。
Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO) and suppresses neuronal apoptotic by inhibiting inflammatory and apoptotic signaling pathways. Flo8 can be used for Parkinson's Disease (PD) research.
体内研究：
Compound Flo8 (15/35 mg/kg，腹腔注射，每天/两周) 能缓解 MPTP 诱导 C57BL/6J 小鼠大脑中的神经炎症并抑制神经凋亡。Animal Model:MPTP C57BL/6J mice model
Dosage:15 mg/kg, 35 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Increased the mRNA expression of CD86, TNF-α, IL-6 and IL-1β but decreased CD206, Arg-1 and IL-10 in brain tissue.Inhibited the expression of MPTP-induced phosphorylation of p38, ERK, JNK and NF-κ B.Reduced dopamine levels in mouse serum in the MPTP group.Increased the protein expression of Caspase3 and BAX but decreased the expression of Bcl2 after MPTP induction in brain tissue.
体外研究：
Compound Flo8 (5 μM, 10 μM, 18 小时) 对 BV2 细胞活力的抑制作用较小。Compound Flo8 (5 μM, 18小时) 对 BV2 细胞中 ROS 的产生具有明显的抑制作用。Compound Flo8 (5 μM, 10 μM, 18小时) 通过减少 BV2 细胞中炎症因子的表达，降低 SH-SY5Y 细胞的凋亡水平。Compound Flo8 (5 μM, 10 μM, 18小时) 抑制 LPS 诱导的小胶质细胞 M1 极化，促进 M2 极化。Compound Flo8 (5 μM, 10 μM, 18小时) 抑制 LPS 诱导的 BV2 细胞中 ERK，p38 和 JNK 磷酸化。
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