产品
编 号：F756949
分子式：C20H20N2O4
分子量：352.38
分子式：C20H20N2O4
分子量：352.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 2924824-43-9
产品详情
生物活性：
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC50 value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line.
体外研究：
AKR1C3-IN-9 (compound 24) (10-100 μM; 72 h and 96 h) 对 3 种乳腺癌细胞系 (MDA-MB-231、MCF-7) 均有较弱的抗增殖作用，抑制范围为 100 μM。AKR1C3-IN-9 (10 μM, 25 μM, 50 μM; 72 h) 与 10-50 μM DOX 协同抑制 MCF-7 细胞增殖。AKR1C3-IN-9 (10 μM; 8 d) 与 50 μM DOX 协同抑制 MCF-7/DOX 细胞系的增殖、克隆生存，从而恢复对 DOX 的敏感性。
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC50 value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line.
体外研究：
AKR1C3-IN-9 (compound 24) (10-100 μM; 72 h and 96 h) 对 3 种乳腺癌细胞系 (MDA-MB-231、MCF-7) 均有较弱的抗增殖作用，抑制范围为 100 μM。AKR1C3-IN-9 (10 μM, 25 μM, 50 μM; 72 h) 与 10-50 μM DOX 协同抑制 MCF-7 细胞增殖。AKR1C3-IN-9 (10 μM; 8 d) 与 50 μM DOX 协同抑制 MCF-7/DOX 细胞系的增殖、克隆生存，从而恢复对 DOX 的敏感性。
产品资料
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