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编 号：F756926
分子式：C20H22N6O3S2
分子量：458.56
分子式：C20H22N6O3S2
分子量：458.56
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CAS No: 2923800-62-6
产品详情
生物活性：
ATR-IN-23 (Compound 34) is a potent and selective ATR inhibitor with an IC50 of 1.5 nM. ATR-IN-23 has potent antiproliferative effects on LoVo cells and synthetic lethality on HT-29 cells, and can be used in the study of DNA damage response (DDR)-deficient cancers.
体内研究：
ATR-IN-23 在最大浓度为 2000 mg/kg 时表现出急性毒性，在 ICR 小鼠中具有中等安全性。ATR-IN-23 (50 mg/kg；一天一次或一天两次；p.o.；21 天) 在 BALB/c 裸鼠中表现出中等抗肿瘤功效。Animal Model:BALB/c nude mice
Dosage:50 mg/kg
Administration:p.o., once a day or twice a day for 21 consecutive days, dissolved in a solution of DMSO (10%), solutol (10%), and saline (80%)
Result:Exhibited moderate antitumor efficacy, with a tumor growth inhibition (TGI) value of 55% at dosages of 50 mg/kg twice a day.
体外研究：
ATR-IN-23 对 ATR 具有显著的抑制作用，IC50 值为 1.5 nM，对 LoVo 细胞显示出强的抗增殖活性，IC50 值为 0.073 μM。ATR-IN-23 对 HT-29 细胞表现出中等的抗增殖效力，IC50 值为 0.161 μM。
ATR-IN-23 (Compound 34) is a potent and selective ATR inhibitor with an IC50 of 1.5 nM. ATR-IN-23 has potent antiproliferative effects on LoVo cells and synthetic lethality on HT-29 cells, and can be used in the study of DNA damage response (DDR)-deficient cancers.
体内研究：
ATR-IN-23 在最大浓度为 2000 mg/kg 时表现出急性毒性，在 ICR 小鼠中具有中等安全性。ATR-IN-23 (50 mg/kg；一天一次或一天两次；p.o.；21 天) 在 BALB/c 裸鼠中表现出中等抗肿瘤功效。Animal Model:BALB/c nude mice
Dosage:50 mg/kg
Administration:p.o., once a day or twice a day for 21 consecutive days, dissolved in a solution of DMSO (10%), solutol (10%), and saline (80%)
Result:Exhibited moderate antitumor efficacy, with a tumor growth inhibition (TGI) value of 55% at dosages of 50 mg/kg twice a day.
体外研究：
ATR-IN-23 对 ATR 具有显著的抑制作用，IC50 值为 1.5 nM，对 LoVo 细胞显示出强的抗增殖活性，IC50 值为 0.073 μM。ATR-IN-23 对 HT-29 细胞表现出中等的抗增殖效力，IC50 值为 0.161 μM。
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