产品
编 号：F756893
分子式：C20H13NO3
分子量：315.32
分子式：C20H13NO3
分子量：315.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 2922283-43-8
产品详情
生物活性：
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.
体内研究：
UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis.UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h?ng/mL for intra venous (i.v.) and 2527 h?ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose.Animal Model:Diet-induced obesity (DIO) mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection; daily, for 4 weeks
Result:Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.
Animal Model:Diet-induced obesity (DIO) mice
Dosage:5 mg/kg (Pharmacokinetic Analysis)
Administration:Intravenous injection and intraperitoneal injection
Result:1.19routeivip
Dose (mg/kg)55
AUClast (h*ng/mL)60542527
CL (mL/min/kg)13.7
体外研究：
UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP7 levels by 81% and 5-InsP8 levels by 63%.
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.
体内研究：
UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis.UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h?ng/mL for intra venous (i.v.) and 2527 h?ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose.Animal Model:Diet-induced obesity (DIO) mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection; daily, for 4 weeks
Result:Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.
Animal Model:Diet-induced obesity (DIO) mice
Dosage:5 mg/kg (Pharmacokinetic Analysis)
Administration:Intravenous injection and intraperitoneal injection
Result:1.19routeivip
Dose (mg/kg)55
AUClast (h*ng/mL)60542527
CL (mL/min/kg)13.7
体外研究：
UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP7 levels by 81% and 5-InsP8 levels by 63%.
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