产品
编 号：F756871
分子式：C22H30F3N5O4S2
分子量：549.63
分子式：C22H30F3N5O4S2
分子量：549.63
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
结构图
CAS No: 2920904-06-7
产品详情
生物活性：
SARS-CoV-2-IN-41 (compound 2) is a potent SARS-CoV-2 3CLpro inhibitor with an IC50 value of 0.022 μM. SARS-CoV-2-IN-41 shows antiviral effect.
体内研究：
SARS-CoV-2-IN-41 (50、200 mg/kg；腹腔注射) 对 SARS-CoV-2 感染小鼠的抗病毒作用。Animal Model:7-8 weeks, hACE2-K18 transgenic mice (infected with the delta strain of SARS-CoV-2 by intranasal drops)
Dosage:50, 200 mg/kg (combined with 50 mg/kg cytochrome P450 inhibitor ritonavir)
Administration:I.p.; dose on day 0 1 time, 2 times on the 1st day, 1 time on the 2nd day
Result:Significantly reduced the viral load in the lungs, after 4 days of infection, a sustained inhibitory effect of compound 2 on viral copy number was observed.
SARS-CoV-2-IN-41 (compound 2) is a potent SARS-CoV-2 3CLpro inhibitor with an IC50 value of 0.022 μM. SARS-CoV-2-IN-41 shows antiviral effect.
体内研究：
SARS-CoV-2-IN-41 (50、200 mg/kg；腹腔注射) 对 SARS-CoV-2 感染小鼠的抗病毒作用。Animal Model:7-8 weeks, hACE2-K18 transgenic mice (infected with the delta strain of SARS-CoV-2 by intranasal drops)
Dosage:50, 200 mg/kg (combined with 50 mg/kg cytochrome P450 inhibitor ritonavir)
Administration:I.p.; dose on day 0 1 time, 2 times on the 1st day, 1 time on the 2nd day
Result:Significantly reduced the viral load in the lungs, after 4 days of infection, a sustained inhibitory effect of compound 2 on viral copy number was observed.
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