产品
编 号：F756811
分子式：C28H37N3O5S2
分子量：559.74
分子式：C28H37N3O5S2
分子量：559.74
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2914879-10-8
产品详情
生物活性：
KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor with an IC50 of 0.016 μM against KIF18A microtubule-dependent ATPase activity.
体内研究：
KIF18A-IN-6 (Compound 134; 10-60 mg/kg; p.o.; twice or once a day for 1 month) 抑制小鼠 HCC15 和 OVCAR3 肿瘤生长。Animal Model:SCID Beige mice, HCC15 tumor model
Dosage:10, 30 and 60 mg/kg
Administration:PO, twice a day for 1 month
Result:Inhibited tumor growth by 61±10%, 89±7% and 94±5% at 10, 30 and 60 mg/kg, respectively.
Animal Model:Balb/C nude mice, OVCAR3 tumor model
Dosage:10, 30 and 60 mg/kg
Administration:PO, twice or once a day for 1 month
Result:Completely inhibited tumor growth (over 100%) over 30 mg/kg.
体外研究：
KIF18A-IN-6 (Compound 134; 7 days) 抑制 JIMT-1、HCC-15 和 NIH-OVCAR3 细胞活力，IC50 分别为 0.0040、0.0051 和 0.0051 μM。
KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor with an IC50 of 0.016 μM against KIF18A microtubule-dependent ATPase activity.
体内研究：
KIF18A-IN-6 (Compound 134; 10-60 mg/kg; p.o.; twice or once a day for 1 month) 抑制小鼠 HCC15 和 OVCAR3 肿瘤生长。Animal Model:SCID Beige mice, HCC15 tumor model
Dosage:10, 30 and 60 mg/kg
Administration:PO, twice a day for 1 month
Result:Inhibited tumor growth by 61±10%, 89±7% and 94±5% at 10, 30 and 60 mg/kg, respectively.
Animal Model:Balb/C nude mice, OVCAR3 tumor model
Dosage:10, 30 and 60 mg/kg
Administration:PO, twice or once a day for 1 month
Result:Completely inhibited tumor growth (over 100%) over 30 mg/kg.
体外研究：
KIF18A-IN-6 (Compound 134; 7 days) 抑制 JIMT-1、HCC-15 和 NIH-OVCAR3 细胞活力，IC50 分别为 0.0040、0.0051 和 0.0051 μM。
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