产品
编 号：F756698
分子式：C33H38N4O6
分子量：586.68
分子式：C33H38N4O6
分子量：586.68
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2894733-91-4
产品详情
生物活性：
PD-L1-IN-2 is a potential tumor immunological agent by inhibiting PD-L1. PD-L1-IN-2 is a Naamidine J derivative and exerts antitumor effects in vivo by reducing PD-L1 expression and enhancing tumor-infiltrating T-cell immunity. PD-L1-IN-2 is used for colorectal cancer research.
体内研究：
PD-L1-IN-2 (compound 11c) (i.p.; 25/50 mg/kg; once a day; 16 days) 可使肿瘤减小，50 mg/kg 组的抑制率为 45%，50 mg/kg 组的平均肿瘤重量显著低于PBS组。Animal Model:C57BL/6 mice with subcutaneous MC38 tumors
Dosage:25/50 mg/kg
Administration:i.p.; 25/50 mg/kg; once a day; 16 days
Result:Suppressed MC38 tumor growth in vivo.
体外研究：
PD-L1-IN-2 (compound 11c) 对 RKO 细胞的抑制作用IC50值为 31.7μM。PD-L1-IN-2 (0-10 μM; 0-24 hours) 抑制 RKO 细胞中 PD-L1 表达呈剂量依赖性和时间依赖性。PD-L1-IN-2 (0-10 μM; 0-24 hours) 促进 PD-L1 蛋白的周转。在 CHX 脉冲追逐中，PD-L1-IN-2 处理的细胞中 PD-L1 周转率比未处理的细胞要快.
PD-L1-IN-2 is a potential tumor immunological agent by inhibiting PD-L1. PD-L1-IN-2 is a Naamidine J derivative and exerts antitumor effects in vivo by reducing PD-L1 expression and enhancing tumor-infiltrating T-cell immunity. PD-L1-IN-2 is used for colorectal cancer research.
体内研究：
PD-L1-IN-2 (compound 11c) (i.p.; 25/50 mg/kg; once a day; 16 days) 可使肿瘤减小，50 mg/kg 组的抑制率为 45%，50 mg/kg 组的平均肿瘤重量显著低于PBS组。Animal Model:C57BL/6 mice with subcutaneous MC38 tumors
Dosage:25/50 mg/kg
Administration:i.p.; 25/50 mg/kg; once a day; 16 days
Result:Suppressed MC38 tumor growth in vivo.
体外研究：
PD-L1-IN-2 (compound 11c) 对 RKO 细胞的抑制作用IC50值为 31.7μM。PD-L1-IN-2 (0-10 μM; 0-24 hours) 抑制 RKO 细胞中 PD-L1 表达呈剂量依赖性和时间依赖性。PD-L1-IN-2 (0-10 μM; 0-24 hours) 促进 PD-L1 蛋白的周转。在 CHX 脉冲追逐中，PD-L1-IN-2 处理的细胞中 PD-L1 周转率比未处理的细胞要快.
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