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编 号：F756649
分子式：C38H53N11O12S
分子量：887.96
分子式：C38H53N11O12S
分子量：887.96
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CAS No: 2891451-07-1
产品详情
生物活性：
RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC50 value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin.
体外研究：
RNA polymerase II-IN-1 (compound 19iv) has cytotoxicity against CHO, HEK293 and HeLa with IC50s of 0.19 μM, 0.20 μM and 3.32 μM, respectively; exhibits 2.7-fold less toxicity than α-Amanitin in HepG2 with an IC50 of 5.6 μM.
RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC50 value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin.
体外研究：
RNA polymerase II-IN-1 (compound 19iv) has cytotoxicity against CHO, HEK293 and HeLa with IC50s of 0.19 μM, 0.20 μM and 3.32 μM, respectively; exhibits 2.7-fold less toxicity than α-Amanitin in HepG2 with an IC50 of 5.6 μM.
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