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编 号：F756604
分子式：C25H21N3O4
分子量：427.45
分子式：C25H21N3O4
分子量：427.45
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CAS No: 2883436-66-4
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生物活性：
Tubulin inhibitor 13 (E27) is a potent tubulin inhibitor with an IC50 value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity.
体外研究：
Tubulin inhibitor 13 (E27) (0-100 μM, 72 h) exhibits antitumor activity with the IC50 values of 9.32 μM, 10.36μM and 7.81 μM against HepG2, A549 and HCT116, respectively, and shows cytotoxic effect on 293 T (human embryonic kidney cell) with an IC50 value of 49.30 μM.Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) causes destruction, fragmentation and disintegration of microtubules, and significantly reduces cell migration in a dose-dependent manner in A549 cells.Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) induces apoptosis in a dose-dependent manner and blocks the cell cycle in the G2/M phase in A549 cells.Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) promotes the expression of pro-apoptotic markers such as BAX, cleaved caspase-3 and cleaved caspase-9 and decreases the expression of the anti-apoptotic protein Bcl-2 in A549 cells.
Tubulin inhibitor 13 (E27) is a potent tubulin inhibitor with an IC50 value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity.
体外研究：
Tubulin inhibitor 13 (E27) (0-100 μM, 72 h) exhibits antitumor activity with the IC50 values of 9.32 μM, 10.36μM and 7.81 μM against HepG2, A549 and HCT116, respectively, and shows cytotoxic effect on 293 T (human embryonic kidney cell) with an IC50 value of 49.30 μM.Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) causes destruction, fragmentation and disintegration of microtubules, and significantly reduces cell migration in a dose-dependent manner in A549 cells.Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) induces apoptosis in a dose-dependent manner and blocks the cell cycle in the G2/M phase in A549 cells.Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) promotes the expression of pro-apoptotic markers such as BAX, cleaved caspase-3 and cleaved caspase-9 and decreases the expression of the anti-apoptotic protein Bcl-2 in A549 cells.
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