产品
编 号：F756510
分子式：C22H19N3O5
分子量：405.4
分子式：C22H19N3O5
分子量：405.4
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CAS No: 2873383-67-4
产品详情
生物活性：
Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis.
体内研究：
Tubulin inhibitor 30 (Compound 15) (25mg/kg; i.p.; every 2 days) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe2+ accumulation in mice.Animal Model:BALB/Cnu/nu mice, U-87 MG or SKOV-3 model
Dosage:25 mg/kg
Administration:Intraperitoneal injection, every 2 days
Result:Inhibited tumorigenicity and tumor volume. Caused oxidative stress injury and Fe2+ accumulation.
体外研究：
Tubulin inhibitor 30 (Compound 15) (0-100 nM; 48 h) inhibits the viability of MCF-7, U-87 MG and OVCAR-3 cells.Tubulin inhibitor 30 is metabolically stable when incubated with human liver microsomes.
Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis.
体内研究：
Tubulin inhibitor 30 (Compound 15) (25mg/kg; i.p.; every 2 days) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe2+ accumulation in mice.Animal Model:BALB/Cnu/nu mice, U-87 MG or SKOV-3 model
Dosage:25 mg/kg
Administration:Intraperitoneal injection, every 2 days
Result:Inhibited tumorigenicity and tumor volume. Caused oxidative stress injury and Fe2+ accumulation.
体外研究：
Tubulin inhibitor 30 (Compound 15) (0-100 nM; 48 h) inhibits the viability of MCF-7, U-87 MG and OVCAR-3 cells.Tubulin inhibitor 30 is metabolically stable when incubated with human liver microsomes.
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