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编 号：F756497
分子式：C13H19F3N2O5Pt
分子量：535.38
分子式：C13H19F3N2O5Pt
分子量：535.38
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CAS No: 2870703-23-2
产品详情
生物活性：
Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells.
体内研究：
Antitumor agent-78 (compound 2b) (6 μg/kg; i.v.; injected on day 8, 10, 12) displays better potential antitumor activity than Oxaliplatin (HY-17371), without significant damage to kidney and liver as well as weight loss.Animal Model:A549 xenograft models in mouse
Dosage:6 μg/kg
Administration:Intravenous injection; administration on day 8, 10, 12 after establishing xenograft models (A549 cells; s.c.)
Result:Significantly repressed tumor growth, and maintained normal kidney and liver architecture in mice.
体外研究：
Antitumor agent-78 (compound 2b) (30 μM; 4 h) exhibits good liposoluble and improved cellular uptake in A549 cancer cells.Antitumor agent-78 (20 μM; 36 h) produces cytotoxicity by inducing apoptosis of A549 cancer cells.Antitumor agent-78 (20 μM; 24 h) results in significant down-regulation of Bcl-2 and upregulation of Bax, also leads to E-cadherin increase, Vimentin decrease.Antitumor agent-78 (20 μM; 24 h) arrests cell cycle at S phase and G2/M phase.Antitumor agent-78 (10 μM; 12 h) inhibits cells migration with inhibition rate of 53%.
Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells.
体内研究：
Antitumor agent-78 (compound 2b) (6 μg/kg; i.v.; injected on day 8, 10, 12) displays better potential antitumor activity than Oxaliplatin (HY-17371), without significant damage to kidney and liver as well as weight loss.Animal Model:A549 xenograft models in mouse
Dosage:6 μg/kg
Administration:Intravenous injection; administration on day 8, 10, 12 after establishing xenograft models (A549 cells; s.c.)
Result:Significantly repressed tumor growth, and maintained normal kidney and liver architecture in mice.
体外研究：
Antitumor agent-78 (compound 2b) (30 μM; 4 h) exhibits good liposoluble and improved cellular uptake in A549 cancer cells.Antitumor agent-78 (20 μM; 36 h) produces cytotoxicity by inducing apoptosis of A549 cancer cells.Antitumor agent-78 (20 μM; 24 h) results in significant down-regulation of Bcl-2 and upregulation of Bax, also leads to E-cadherin increase, Vimentin decrease.Antitumor agent-78 (20 μM; 24 h) arrests cell cycle at S phase and G2/M phase.Antitumor agent-78 (10 μM; 12 h) inhibits cells migration with inhibition rate of 53%.
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