产品
编 号：F756489
分子式：C31H30ClF3N8O5
分子量：687.07
分子式：C31H30ClF3N8O5
分子量：687.07
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2869954-98-1
产品详情
生物活性：
Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 μM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity.
体内研究：
Werner syndrome RecQ helicase-IN-3 (120 mg/kg; daily for 22 days) 在小鼠体内显示出抗癌活性。Animal Model:Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)
Dosage:120 mg/kg
Administration:P.o.; daily for 22 days
Result:Inhibited tumor growth.
体外研究：
Werner syndrome RecQ helicase-IN-3 (example 96) (0-10 μM; 8-20 days) 显示抗增殖活性，对 SW48，DLD1 WRN-KO 细胞的 GI50s 值分别为 0.06，>10 μM。
Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 μM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity.
体内研究：
Werner syndrome RecQ helicase-IN-3 (120 mg/kg; daily for 22 days) 在小鼠体内显示出抗癌活性。Animal Model:Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)
Dosage:120 mg/kg
Administration:P.o.; daily for 22 days
Result:Inhibited tumor growth.
体外研究：
Werner syndrome RecQ helicase-IN-3 (example 96) (0-10 μM; 8-20 days) 显示抗增殖活性，对 SW48，DLD1 WRN-KO 细胞的 GI50s 值分别为 0.06，>10 μM。
产品资料
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