产品
编 号：F756466
分子式：C28H41N5O3
分子量：495.66
分子式：C28H41N5O3
分子量：495.66
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 2866408-21-9
产品详情
生物活性：
MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC50 values of 100 nM (G9a) and 140 nM (GLP), and Kd values of 44 nM (G9a) and 46 nM (GLP). MS8511 reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer, and other disease such as Alzheimer’s disease (AD), sickle cell disease, Prader?Willi syndrome (PWS).
体外研究：
MS8511 (Compound 8, 0-100 μΜ, 10 min) selectively inhibits G9a and GLP against other PKMTs and PRMTs, with IC50 values of 100 nM (G9a) and 140 nM (GLP).MS8511 (50 min) prefers covalent modification for G9a over GLP, with Kd values of 44 nM (G9a) and 46 nM (GLP).MS8511 (0-5 μM, 24-72 h) effectively reduces the H3K9me2 mark in MDA-MB-231 and K562 cellssup>.MS8511 (0.8-25 μM, 3 days) inhibits the growth of MDA-MB-231 cells.
MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC50 values of 100 nM (G9a) and 140 nM (GLP), and Kd values of 44 nM (G9a) and 46 nM (GLP). MS8511 reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer, and other disease such as Alzheimer’s disease (AD), sickle cell disease, Prader?Willi syndrome (PWS).
体外研究：
MS8511 (Compound 8, 0-100 μΜ, 10 min) selectively inhibits G9a and GLP against other PKMTs and PRMTs, with IC50 values of 100 nM (G9a) and 140 nM (GLP).MS8511 (50 min) prefers covalent modification for G9a over GLP, with Kd values of 44 nM (G9a) and 46 nM (GLP).MS8511 (0-5 μM, 24-72 h) effectively reduces the H3K9me2 mark in MDA-MB-231 and K562 cellssup>.MS8511 (0.8-25 μM, 3 days) inhibits the growth of MDA-MB-231 cells.
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