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编 号:F756461
分子式:C27H23ClN2O5S
分子量:523
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生物活性:
MurA-IN-3 is a reversible pyrrolidinedione-based MurA inhibitor. MurA-IN-3 has inhibitory activity for MurA with an IC50 value of 4.5 μM. MurA-IN-3 also has antibacterial activity.

体外研究:
MurA-IN-3 has inhibitory activity for MurA and C115D MurA mutant with IC50 values of 4.5 μM and 4.9 μM, respectively.MurA-IN-3 (0-100 μM; 24 h) has no cytotoxicity on both MRC-5 and HepG2 cell lines.MurA-IN-3 has antibacterial activity and pronounced stability.
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