产品
编 号：F756392
分子式：C29H33ClN6O2S
分子量：565.13
分子式：C29H33ClN6O2S
分子量：565.13
产品类型
规格
价格
是否有货
结构图
CAS No: 2857112-07-1
产品详情
生物活性：
PF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 hydrochloride inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 hydrochloride also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM.
体内研究：
PF-6870961 hydrochloride (40 mg/kg；腹腔注射) 抑制饱食和禁食大鼠的食物摄入。Animal Model:Satiated and fasted rats model
Dosage:2.5 mg/kg, 10 mg/kg, and 40 mg/kg
Administration:Intraperitoneal injection
Result:Significantly reduced food intake at 40 mg/kg.
PF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 hydrochloride inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 hydrochloride also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM.
体内研究：
PF-6870961 hydrochloride (40 mg/kg；腹腔注射) 抑制饱食和禁食大鼠的食物摄入。Animal Model:Satiated and fasted rats model
Dosage:2.5 mg/kg, 10 mg/kg, and 40 mg/kg
Administration:Intraperitoneal injection
Result:Significantly reduced food intake at 40 mg/kg.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备