产品
编 号：F756389
分子式：C15H22N2O4
分子量：294.35
分子式：C15H22N2O4
分子量：294.35
产品类型
规格
价格
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结构图
CAS No: 2857098-30-5
产品详情
生物活性：
SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis.
体内研究：
SAHA-OH (intraperitoneal injection; 50 mg/kg; once) treatment prevents splenic organ damage, and reduces plasma proinflammatory cytokine levels in LPS-induced endotoxemia mouse model.Animal Model:LPS-induced endotoxemia mouse model
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 50 mg/kg; once
Result:Reduced proinflammatory cytokine secretions by about 50% compared to no treatment (NT) control mice.Showed similar architecture as no treatment (NT) control and displayed well-organized lymphoid follicles.
体外研究：
SAHA-OH (0.67-10.76 μM; 51 h) shows inhibition in bone marrow macrophages.SAHA-OH (0.01 μM; 3 h) treatment in BMM?s (bone marrow macrophages) reduces IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2) and GROα (CXCL1) secretions.SAHA-OH (10 μM; 4 or 9 h) treatment induces acetylation of cytoplasmic α-tubulin and nuclear histone H3.SAHA-OH (0-30 μM; 3 h) treatment attenuates macrophage apoptosis.SAHA-OH (0-30 μM; 3 h) treatment attenuates B cell death.
SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis.
体内研究：
SAHA-OH (intraperitoneal injection; 50 mg/kg; once) treatment prevents splenic organ damage, and reduces plasma proinflammatory cytokine levels in LPS-induced endotoxemia mouse model.Animal Model:LPS-induced endotoxemia mouse model
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 50 mg/kg; once
Result:Reduced proinflammatory cytokine secretions by about 50% compared to no treatment (NT) control mice.Showed similar architecture as no treatment (NT) control and displayed well-organized lymphoid follicles.
体外研究：
SAHA-OH (0.67-10.76 μM; 51 h) shows inhibition in bone marrow macrophages.SAHA-OH (0.01 μM; 3 h) treatment in BMM?s (bone marrow macrophages) reduces IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2) and GROα (CXCL1) secretions.SAHA-OH (10 μM; 4 or 9 h) treatment induces acetylation of cytoplasmic α-tubulin and nuclear histone H3.SAHA-OH (0-30 μM; 3 h) treatment attenuates macrophage apoptosis.SAHA-OH (0-30 μM; 3 h) treatment attenuates B cell death.
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