产品
编 号：F756378
分子式：C65H87N9O8S
分子量：1154.51
分子式：C65H87N9O8S
分子量：1154.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2855085-25-3
产品详情
生物活性：
MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC).
体外研究：
MS8815 shows potency in inhibiting the EZH2 and EZH1 methyltransferase activity with IC50 values of 8.6 nM and 62 nM, respectively.MS8815 (0.1-1 μM) degrades EZH2 with a DC50 value of 140 nM in MDA-MB-453 cells.MS8815 (1 μM; 48 h) induces robust EZH2 degradation in a concentration-, time-, and proteasome-dependent manner in TNBC cells.MS8815 (0.1-10 μM; 5 days) effectively suppresses the cell growth in multiple TNBC cell lines and primary patient TNBC cells.
MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC).
体外研究：
MS8815 shows potency in inhibiting the EZH2 and EZH1 methyltransferase activity with IC50 values of 8.6 nM and 62 nM, respectively.MS8815 (0.1-1 μM) degrades EZH2 with a DC50 value of 140 nM in MDA-MB-453 cells.MS8815 (1 μM; 48 h) induces robust EZH2 degradation in a concentration-, time-, and proteasome-dependent manner in TNBC cells.MS8815 (0.1-10 μM; 5 days) effectively suppresses the cell growth in multiple TNBC cell lines and primary patient TNBC cells.
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