产品
编 号：F756370
分子式：C28H25N5O2
分子量：463.53
分子式：C28H25N5O2
分子量：463.53
产品类型
规格
价格
是否有货
结构图
CAS No: 2851977-85-8
产品详情
生物活性：
ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile.
体外研究：
ZLHQ-5f shows antiproliferative activity with GI50 values of 0.949 ± 0.113, 0.821 ± 0.240, 1.124 ± 0.362, 1.945 ± 0.278 and 3.349 ± 0.149 μM against A549, HCT116, MCF-7, HepG2 and LO2 cells, respectively.
ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile.
体外研究：
ZLHQ-5f shows antiproliferative activity with GI50 values of 0.949 ± 0.113, 0.821 ± 0.240, 1.124 ± 0.362, 1.945 ± 0.278 and 3.349 ± 0.149 μM against A549, HCT116, MCF-7, HepG2 and LO2 cells, respectively.
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