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编 号:F756311
分子式:C26H28BrF3N4O2
分子量:565.43
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生物活性:
Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase.

体内研究:
Antifungal agent 46 (compound 2f, 0.78 μM) inhibits FTase activity in vivo.

体外研究:
Antifungal agent 46 (compound 2f) inhibits growth at 12.5 μM in biofilm assay, corresponding to a 2-fold higher MIC than Amphotericin B (HY-B0221).
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