产品
编 号：F756273
分子式：C8H8Br2N2O4S
分子量：388.03
分子式：C8H8Br2N2O4S
分子量：388.03
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
询价
询价
25mg
询价
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50mg
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询价
结构图
CAS No: 2837000-75-4
产品详情
生物活性：
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research.
体内研究：
1.19Plasma PK Parameters in Healthy Mice CompoundSPAA-52
dose route2 mg/kg IV10 mg/kg PO
AUC (0?8 h) (nM h)15,10037,300
C0 or Cmax (nM)13,4009690
C0 or Cmax unbound (nM)332233
Vdss (L/kg)0.42
CL (mL/min/kg)5.65
T1/2 (h)1.414.2
F (%) 34
1.19Plasma PK Parameters in Healthy Rats CompoundSPAA-52
dose route3 mg/kg PO
AUC (0-12 h) (nM h)4660
Cmax (nM)877
Cmax unbound (nM)21
Vdss (L/kg)0.42
Tmax (h)2.0
T1/2 (h)2.4
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research.
体内研究：
1.19Plasma PK Parameters in Healthy Mice CompoundSPAA-52
dose route2 mg/kg IV10 mg/kg PO
AUC (0?8 h) (nM h)15,10037,300
C0 or Cmax (nM)13,4009690
C0 or Cmax unbound (nM)332233
Vdss (L/kg)0.42
CL (mL/min/kg)5.65
T1/2 (h)1.414.2
F (%) 34
1.19Plasma PK Parameters in Healthy Rats CompoundSPAA-52
dose route3 mg/kg PO
AUC (0-12 h) (nM h)4660
Cmax (nM)877
Cmax unbound (nM)21
Vdss (L/kg)0.42
Tmax (h)2.0
T1/2 (h)2.4
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