产品
编 号：F756259
分子式：C24H19ClFN5O2
分子量：463.89
分子式：C24H19ClFN5O2
分子量：463.89
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CAS No: 2834087-82-8
产品详情
生物活性：
HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (KD=2.50 μM) and inhibitory activity (IC50=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC50s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056).
体内研究：
HIV-1 inhibitor-51 (化合物 36a·HCl; 2 mg/kg; 静脉给药) 的 T1/2 为 1.43 小时，CL 为 103 L/h·kg，Cmax 为 484 ng/mL。 HIV-1 inhibitor-51 (10 mg/kg; 口服) 的 T1/2 为 5.12 小时，Cmax 为 37.5 ng/mL。 Animal Model:ICR mice
Dosage:2 mg/kg (Pharmacokinetic Analysis)
Administration:IV
Result:Had a T1/2 of 5.12 hours, and Cmax of 37.5 ng/mL.
HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (KD=2.50 μM) and inhibitory activity (IC50=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC50s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056).
体内研究：
HIV-1 inhibitor-51 (化合物 36a·HCl; 2 mg/kg; 静脉给药) 的 T1/2 为 1.43 小时，CL 为 103 L/h·kg，Cmax 为 484 ng/mL。 HIV-1 inhibitor-51 (10 mg/kg; 口服) 的 T1/2 为 5.12 小时，Cmax 为 37.5 ng/mL。 Animal Model:ICR mice
Dosage:2 mg/kg (Pharmacokinetic Analysis)
Administration:IV
Result:Had a T1/2 of 5.12 hours, and Cmax of 37.5 ng/mL.
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