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编 号：F756255
分子式：C8H12N2S2
分子量：200.32
分子式：C8H12N2S2
分子量：200.32
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CAS No: 2833772-94-2
产品详情
生物活性：
Antifungal agent 38 is a geterocyclic disulfide, an antifungal and antibacterial agent. Antifungal agent 38 induces the shrinkage of hyphae, disrupts the integrity of the plasma membrane, and causes the damage and leakage of cell contents.
体内研究：
Antifungal agent 38 (compound S8) (200 μg/mL) displays equivalent curative and higher protective effects as the positive drug Thiophanate-Methyl (HY-B0842) in vivo.Antifungal agent 38 (50, 100, 200 μg/mL, 30 mL; sprinkling) applies on pears and inhibits M. fructicola growth in vivo.
体外研究：
Antifungal agent 38 (50 μg/mL) shows anti-fungal activity against 10 pathogenic fungi with inhibition rates of 56.57% (R. solani), 100% (S. sclerotiorum), 55.09% (B. cinerea), 71.23% (F. graminearum), 37.32% (M. oryzae), 50.87% (P. capsici), 100% (A. flavus), 59.75% (P. expansum), 100% (M. fructicola), 65.78% (R. stolonifer), respectively.Antifungal agent 38 (5 μg/mL) damages plasma membrane integrity of M. fructicola.Antifungal agent 38 (100 μg/mL) displays excellent anti-bacterial activity against X. oryzae accc 11602, X. axonpodis.Antifungal agent 38 inhibits fungus growth with EC50s of 17.09 μg/mL (R. solani), 6.34 μg/mL (S. sclerotiorum), 25.24 μg/mL (F. graminearum), >10 μg/mL (A. flavus), 10.42 μg/mL (M. fructicola), 45.71 μg/mL (B. cinerea), respectively.
Antifungal agent 38 is a geterocyclic disulfide, an antifungal and antibacterial agent. Antifungal agent 38 induces the shrinkage of hyphae, disrupts the integrity of the plasma membrane, and causes the damage and leakage of cell contents.
体内研究：
Antifungal agent 38 (compound S8) (200 μg/mL) displays equivalent curative and higher protective effects as the positive drug Thiophanate-Methyl (HY-B0842) in vivo.Antifungal agent 38 (50, 100, 200 μg/mL, 30 mL; sprinkling) applies on pears and inhibits M. fructicola growth in vivo.
体外研究：
Antifungal agent 38 (50 μg/mL) shows anti-fungal activity against 10 pathogenic fungi with inhibition rates of 56.57% (R. solani), 100% (S. sclerotiorum), 55.09% (B. cinerea), 71.23% (F. graminearum), 37.32% (M. oryzae), 50.87% (P. capsici), 100% (A. flavus), 59.75% (P. expansum), 100% (M. fructicola), 65.78% (R. stolonifer), respectively.Antifungal agent 38 (5 μg/mL) damages plasma membrane integrity of M. fructicola.Antifungal agent 38 (100 μg/mL) displays excellent anti-bacterial activity against X. oryzae accc 11602, X. axonpodis.Antifungal agent 38 inhibits fungus growth with EC50s of 17.09 μg/mL (R. solani), 6.34 μg/mL (S. sclerotiorum), 25.24 μg/mL (F. graminearum), >10 μg/mL (A. flavus), 10.42 μg/mL (M. fructicola), 45.71 μg/mL (B. cinerea), respectively.
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