产品
编 号：F756204
分子式：C26H23FN6
分子量：438.5
分子式：C26H23FN6
分子量：438.5
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CAS No: 2827065-28-9
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生物活性：
Antitumor agent-74 (compound 13da) is a quinoxalines derivative, an antitumor agent. Antitumor agent-74 exhibits more potent efficacy on tumor inhibition, mixed with regioisomer Antitumor agent-75 (HY-151295, compound 14 da) (mriBIQ 13da/14da). mriBIQ 13da/14da attests cell cycle at S phase, inhibits DNA synthesis, and induces mithochondrial apoptosis.
体外研究：
Antitumor agent-74 (compound 13da) shows lower cytotoxicity (IC50s=56.7-86.3 μM) against cancer cells than mriBIQ 13da/14da (IC50s=2.8-34.0 μM).mriBIQ 13da/14da shows high selectivity on A549 cells over normal embryonic lung cells (Wi38), with selectivity index of 12 (IC50 of Wi38/A549).mriBIQ 13da/14da (1-100 μM; 48 h) inhibtis A549 cells proliferation and decreases the rate of cell division in A549 cells.
Antitumor agent-74 (compound 13da) is a quinoxalines derivative, an antitumor agent. Antitumor agent-74 exhibits more potent efficacy on tumor inhibition, mixed with regioisomer Antitumor agent-75 (HY-151295, compound 14 da) (mriBIQ 13da/14da). mriBIQ 13da/14da attests cell cycle at S phase, inhibits DNA synthesis, and induces mithochondrial apoptosis.
体外研究：
Antitumor agent-74 (compound 13da) shows lower cytotoxicity (IC50s=56.7-86.3 μM) against cancer cells than mriBIQ 13da/14da (IC50s=2.8-34.0 μM).mriBIQ 13da/14da shows high selectivity on A549 cells over normal embryonic lung cells (Wi38), with selectivity index of 12 (IC50 of Wi38/A549).mriBIQ 13da/14da (1-100 μM; 48 h) inhibtis A549 cells proliferation and decreases the rate of cell division in A549 cells.
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