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编 号：F756170
分子式：C9H8BrF2N
分子量：248.07
分子式：C9H8BrF2N
分子量：248.07
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CAS No: 2821068-07-7
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生物活性：
LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation.
体外研究：
LSD1/2-IN-3 (compound 8c) inhibits proliferation of the T-cell acute lymphoblastic leukemia (T-ALL) with IC50s?of 25 μM (CCRF-CEM) and 27 μM (Jurkat), respectively, without inhibiting the human normal fibroblast cell line WI-38.
LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation.
体外研究：
LSD1/2-IN-3 (compound 8c) inhibits proliferation of the T-cell acute lymphoblastic leukemia (T-ALL) with IC50s?of 25 μM (CCRF-CEM) and 27 μM (Jurkat), respectively, without inhibiting the human normal fibroblast cell line WI-38.
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