产品
编 号：F756155
分子式：C18H21N5O3S
分子量：387.46
分子式：C18H21N5O3S
分子量：387.46
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CAS No: 2820126-50-7
产品详情
生物活性：
EGFR/HER2-IN-6 (compound 43) is an EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-6 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.122, 0.078 and 0.585 μM, respectively. EGFR/HER2-IN-6 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer.
体内研究：
EGFR/HER2-IN-6 (10 mg/kg; i.p. once per day for 20days) shows anti-breast cancer activity in mice.Animal Model:8-week-old swiss albino female mice
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg once per day; for 20 days
Result:Decreased tumor volume 65.3% and reduced body weight 7.4% after 20 days of treatment.
体外研究：
EGFR/HER2-IN-6 (0-100 μM; 72 h) shows remarkable broad spectrum cytotoxic potency, and the cytotoxic potency against MCF7 cells is more potent than SOR.EGFR/HER2-IN-6 (0-20 μM; 0-48 h) affects cell cycle and indeces apoptosis of MCF-7 cells.
EGFR/HER2-IN-6 (compound 43) is an EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-6 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.122, 0.078 and 0.585 μM, respectively. EGFR/HER2-IN-6 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer.
体内研究：
EGFR/HER2-IN-6 (10 mg/kg; i.p. once per day for 20days) shows anti-breast cancer activity in mice.Animal Model:8-week-old swiss albino female mice
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg once per day; for 20 days
Result:Decreased tumor volume 65.3% and reduced body weight 7.4% after 20 days of treatment.
体外研究：
EGFR/HER2-IN-6 (0-100 μM; 72 h) shows remarkable broad spectrum cytotoxic potency, and the cytotoxic potency against MCF7 cells is more potent than SOR.EGFR/HER2-IN-6 (0-20 μM; 0-48 h) affects cell cycle and indeces apoptosis of MCF-7 cells.
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