产品
编 号：F756101
分子式：C22H19N3O2
分子量：357.41
分子式：C22H19N3O2
分子量：357.41
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CAS No: 2810894-92-7
产品详情
生物活性：
LasR-IN-3 is a LasR inhibitor against Pseudomonas aeruginosa. LasR-IN-3 induces LasR structure instability and completely dissociates LasR functioning dimeric form.
体外研究：
LasR-IN-3 (compound 7f) (4.68-150 μg/mL; 24 h) shows anti-activity against Pseudomonas aeruginosa with MIC and sub-MIC values of 56.25 μg/mL and 14.00 μg/mL. LasR-IN-3 (14.00 μg/mL; 24 h, or 48 h) inhibits biofilm formation, pyocyanin, and rhamnolipids production with inhibition rate of 71.70%, 68.70%, 54.00%, respectively. LasR-IN-3 (56.25 μg/mL, and 338.0 μg/mL; 24 h) is safe to normal cell line (HDFa). LasR-IN-3 (14.00 μg/mL; 24 h) decreases lasR and rhlR gene expression and inhibits the QS-dependent biofilm formation and virulence factors.
LasR-IN-3 is a LasR inhibitor against Pseudomonas aeruginosa. LasR-IN-3 induces LasR structure instability and completely dissociates LasR functioning dimeric form.
体外研究：
LasR-IN-3 (compound 7f) (4.68-150 μg/mL; 24 h) shows anti-activity against Pseudomonas aeruginosa with MIC and sub-MIC values of 56.25 μg/mL and 14.00 μg/mL. LasR-IN-3 (14.00 μg/mL; 24 h, or 48 h) inhibits biofilm formation, pyocyanin, and rhamnolipids production with inhibition rate of 71.70%, 68.70%, 54.00%, respectively. LasR-IN-3 (56.25 μg/mL, and 338.0 μg/mL; 24 h) is safe to normal cell line (HDFa). LasR-IN-3 (14.00 μg/mL; 24 h) decreases lasR and rhlR gene expression and inhibits the QS-dependent biofilm formation and virulence factors.
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