产品
编 号：F756075
分子式：C24H39F2N3O5
分子量：487.58
分子式：C24H39F2N3O5
分子量：487.58
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CAS No: 2803866-44-4
产品详情
生物活性：
HDAC6-IN-12 (compound GZ) is a potent HDAC6 inhibitor. HDAC6-IN-12 has anticancer activity through merges into DNA strands causing DNA damage. HDAC6-IN-12 can be used for cancer research.
体内研究：
HDAC6-IN-12 (compound GZ) (5-10 mg/kg; i.p.; once every three days, for 15 d; bablc female mice) inhibits tumor growth in a dose-dependent manner.Animal Model:Bablc female mice
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; once every three days, for 15 days
Result:Inhibited tumor growth with TGI of 73.2% at 5 mg/kg and 83.8% at 10 mg/kg, respectively.
体外研究：
HDAC6-IN-12 (compound GZ) (72 h) has anti-proliferative activity on tumor cells against HuH-7, HeLa, MDA-MB-231, SKOV3, A549, PANC-1, HCT-116, SGC7901 and 4T1 cells with IC50 values of 0.12 μM, 0.43 μM, 0.14 μM, 0.62 μM, 0.14 μM, 1.08 μM, 0.30 μM, 3.70 μM and 0.66 μM, respectively.HDAC6-IN-12 (compound GZ) (0-3 μM; 24 h; MBA-MB-231 cells) merges into DNA strands causing DNA damage and increases the level of phospho-γ-H2A.X, which is the marker of DNA strand break.HDAC6-IN-12 (compound GZ) (0-100 μM; 30 min) has major metabolic enzymes including CYP3A2, CYP1A1/2 isoforms.
HDAC6-IN-12 (compound GZ) is a potent HDAC6 inhibitor. HDAC6-IN-12 has anticancer activity through merges into DNA strands causing DNA damage. HDAC6-IN-12 can be used for cancer research.
体内研究：
HDAC6-IN-12 (compound GZ) (5-10 mg/kg; i.p.; once every three days, for 15 d; bablc female mice) inhibits tumor growth in a dose-dependent manner.Animal Model:Bablc female mice
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; once every three days, for 15 days
Result:Inhibited tumor growth with TGI of 73.2% at 5 mg/kg and 83.8% at 10 mg/kg, respectively.
体外研究：
HDAC6-IN-12 (compound GZ) (72 h) has anti-proliferative activity on tumor cells against HuH-7, HeLa, MDA-MB-231, SKOV3, A549, PANC-1, HCT-116, SGC7901 and 4T1 cells with IC50 values of 0.12 μM, 0.43 μM, 0.14 μM, 0.62 μM, 0.14 μM, 1.08 μM, 0.30 μM, 3.70 μM and 0.66 μM, respectively.HDAC6-IN-12 (compound GZ) (0-3 μM; 24 h; MBA-MB-231 cells) merges into DNA strands causing DNA damage and increases the level of phospho-γ-H2A.X, which is the marker of DNA strand break.HDAC6-IN-12 (compound GZ) (0-100 μM; 30 min) has major metabolic enzymes including CYP3A2, CYP1A1/2 isoforms.
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