产品
编 号：F756074
分子式：C19H22N2O5
分子量：358.39
分子式：C19H22N2O5
分子量：358.39
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CAS No: 2803866-22-8
产品详情
生物活性：
HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and Hsp90, with IC50s of 105.7 and 61 nM, respectively. HDAC6/HSP90-IN-2 can be used for the research of cancer.
体内研究：
HDAC6/HSP90-IN-2 (25-50 mg/kg; i.p. every weekdays for 6 weeks) exhibits antitumor activity of in NOD-scid IL2Rgammanull (NSG) mice with xenotransplantation of H1975 cells.Animal Model:NOD-scid IL2Rgammanull (NSG) mouse with H1975 cells xenograft
Dosage:25-50 mg/kg
Administration:Intraperitoneal injection; 25-50 mg/kg for every weekdays; for 6 weeks
Result:Delayed tumor growth after 2 weeks and reduced the growth rates of tumors in mice.
体外研究：
HDAC6/HSP90-IN-2 (compound 6e) (0.05-2 μM; 24 h) effects HSP90, HDAC6 and signaling pathways regulated by Hsp90 dose-dependently.HDAC6/HSP90-IN-2 (compound 6e) (2 μM; 24 h) promotes the acetylation of HSP90.HDAC6/HSP90-IN-2 (compound 6e) (0-100 μM; 24-72 h) inhibits the growth of H1975 non-small cell lung cancer cells.HDAC6/HSP90-IN-2 (compound 6e) (0-2 μM; 24 h) induces apoptosis of H1975 cells.
HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and Hsp90, with IC50s of 105.7 and 61 nM, respectively. HDAC6/HSP90-IN-2 can be used for the research of cancer.
体内研究：
HDAC6/HSP90-IN-2 (25-50 mg/kg; i.p. every weekdays for 6 weeks) exhibits antitumor activity of in NOD-scid IL2Rgammanull (NSG) mice with xenotransplantation of H1975 cells.Animal Model:NOD-scid IL2Rgammanull (NSG) mouse with H1975 cells xenograft
Dosage:25-50 mg/kg
Administration:Intraperitoneal injection; 25-50 mg/kg for every weekdays; for 6 weeks
Result:Delayed tumor growth after 2 weeks and reduced the growth rates of tumors in mice.
体外研究：
HDAC6/HSP90-IN-2 (compound 6e) (0.05-2 μM; 24 h) effects HSP90, HDAC6 and signaling pathways regulated by Hsp90 dose-dependently.HDAC6/HSP90-IN-2 (compound 6e) (2 μM; 24 h) promotes the acetylation of HSP90.HDAC6/HSP90-IN-2 (compound 6e) (0-100 μM; 24-72 h) inhibits the growth of H1975 non-small cell lung cancer cells.HDAC6/HSP90-IN-2 (compound 6e) (0-2 μM; 24 h) induces apoptosis of H1975 cells.
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