产品
编 号：F756019
分子式：C19H20N2O3
分子量：324.37
分子式：C19H20N2O3
分子量：324.37
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 2790481-63-7
产品详情
生物活性：
NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. NAMPT activator-3 effectively protects cultured cells from FK866 (HY-50876)-mediated toxicity. NAMPT activator-3 exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without any overt toxicity.
体内研究：
NAMPT activator-3 (化合物 72; 1 or 3 mg/kg; 腹腔给药; 每天一次; 持续一周; 然后给药紫杉醇) 通过增强 NAD 的产生来保护外周感觉神经元免受紫杉醇 (HY-B0015) 诱导的损伤。 Pharmacokinetic Parameters of NAMPT activator-3 in mice.IV (1 mg/kg)IP (30 mg/kg) PO (30 mg/kg)
Tmax (h)0.25
Cmax (ng/mL) 1563188
AUClast (h?ng/mL)1831333388
T1/2 (h)0.181.051.34
CL (mL/min/kg)90.4
Vss (mL/kg)1130
F (%)24.27.05
Animal Model:C57BL/6J mice
Dosage:1 or 3 mg/kg
Administration:IP; daily for one week followed by Taxol (18.3 mg/kg; ip; on day 9, 11, and 13)
Result:Showed a dose-dependent effect on elevation of paw withdrawal threshold. Largely restored the density of myelinated fibers relative to the vehicle control group. Significantly elevate NAD level in the sciatic nerves.
体外研究：
NAMPT activator-3 (化合物 72; 0.1, 0.3, 1, 3, 10 μM; 72 小时) 对包括骨肉瘤细胞 (U2OS)、胶质母细胞瘤细胞 (T98G)、神经母细胞瘤细胞 (SH-SY5Y) 和肝癌细胞 (HepG2) 在内的细胞活力没有副作用。
NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. NAMPT activator-3 effectively protects cultured cells from FK866 (HY-50876)-mediated toxicity. NAMPT activator-3 exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without any overt toxicity.
体内研究：
NAMPT activator-3 (化合物 72; 1 or 3 mg/kg; 腹腔给药; 每天一次; 持续一周; 然后给药紫杉醇) 通过增强 NAD 的产生来保护外周感觉神经元免受紫杉醇 (HY-B0015) 诱导的损伤。 Pharmacokinetic Parameters of NAMPT activator-3 in mice.IV (1 mg/kg)IP (30 mg/kg) PO (30 mg/kg)
Tmax (h)0.25
Cmax (ng/mL) 1563188
AUClast (h?ng/mL)1831333388
T1/2 (h)0.181.051.34
CL (mL/min/kg)90.4
Vss (mL/kg)1130
F (%)24.27.05
Animal Model:C57BL/6J mice
Dosage:1 or 3 mg/kg
Administration:IP; daily for one week followed by Taxol (18.3 mg/kg; ip; on day 9, 11, and 13)
Result:Showed a dose-dependent effect on elevation of paw withdrawal threshold. Largely restored the density of myelinated fibers relative to the vehicle control group. Significantly elevate NAD level in the sciatic nerves.
体外研究：
NAMPT activator-3 (化合物 72; 0.1, 0.3, 1, 3, 10 μM; 72 小时) 对包括骨肉瘤细胞 (U2OS)、胶质母细胞瘤细胞 (T98G)、神经母细胞瘤细胞 (SH-SY5Y) 和肝癌细胞 (HepG2) 在内的细胞活力没有副作用。
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