产品
编 号：F756016
分子式：C25H18N6O2
分子量：434.45
分子式：C25H18N6O2
分子量：434.45
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CAS No: 2789676-44-2
产品详情
生物活性：
HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC50 values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity.
体外研究：
HIV-1 inhibitor-40 (Compound 4ab) displays inhibitory activity with EC50 values of 0.019 ± 0.005, 0.004 ± 0.001, 0.029 ± 0.007, 0.570 ± 0.099 and 0.009 ± 0.006 μM against L100I, K103N, Y181C, Y188L and E138K HIV-1 mutant strains, respectively.
HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC50 values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity.
体外研究：
HIV-1 inhibitor-40 (Compound 4ab) displays inhibitory activity with EC50 values of 0.019 ± 0.005, 0.004 ± 0.001, 0.029 ± 0.007, 0.570 ± 0.099 and 0.009 ± 0.006 μM against L100I, K103N, Y181C, Y188L and E138K HIV-1 mutant strains, respectively.
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