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编 号：F756015
分子式：C26H20F5N3O5
分子量：549.45
分子式：C26H20F5N3O5
分子量：549.45
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CAS No: 2789629-84-9
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生物活性：
DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling.
体内研究：
DCZ19931 (1 μL, 1 μg/μL; 静脉注射; 单剂量) 抑制小鼠氧诱导视网膜病变 (OIR) 模型眼新生血管生成.DCZ19931 (2 μL, 1 μg/μL; 静脉注射; 7 d) 无组织毒性，并抑制激光诱导脉络膜新生血管 (CNV) 模型小鼠的眼部新生血管生成。Animal Model:Laser-induced choroidal neovascularization (CNV) model in mice
Dosage:2 μL, 1 μg/μL
Administration:Intravitreal injection; single dose, monitored for 7 d following laser photocoagulation
Result:Did not cause marked histopathological changes in retinal structures.Decreased the areas of CNV lesions, showed anti-angiogenic effect in vivo.
Animal Model:Oxygen-induced retinopathy (OIR) model in mice
Dosage:1 μL, 1 μg/μL
Administration:Intravitreal injection; single dose
Result:Further showed anti-angiogenic effect in vivo, inhibited ocular neovascularization.
体外研究：
DCZ19931 (1 nM-10 μM; 24 h) 对人脐静脉内皮细胞 (HUVECs) 无明显的细胞毒性。DCZ19931 (500 nM; 24 h) 抑制 (10 ng/mL; 12 h) VEGFs 诱导的内皮细胞增殖、迁移和成管能力。DCZ19931 (500 nM; 24 h) 通过下调 ICAM-1，表达抑制血管通透性。DCZ19931 (500 nM; 24 h) 降低 HUVECs 中 p-ERK1/2、p-p38 和 p-JNK 的表达水平。DCZ19931 在小鼠脉络膜发芽试验中也显示出抗血管生成作用。
DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling.
体内研究：
DCZ19931 (1 μL, 1 μg/μL; 静脉注射; 单剂量) 抑制小鼠氧诱导视网膜病变 (OIR) 模型眼新生血管生成.DCZ19931 (2 μL, 1 μg/μL; 静脉注射; 7 d) 无组织毒性，并抑制激光诱导脉络膜新生血管 (CNV) 模型小鼠的眼部新生血管生成。Animal Model:Laser-induced choroidal neovascularization (CNV) model in mice
Dosage:2 μL, 1 μg/μL
Administration:Intravitreal injection; single dose, monitored for 7 d following laser photocoagulation
Result:Did not cause marked histopathological changes in retinal structures.Decreased the areas of CNV lesions, showed anti-angiogenic effect in vivo.
Animal Model:Oxygen-induced retinopathy (OIR) model in mice
Dosage:1 μL, 1 μg/μL
Administration:Intravitreal injection; single dose
Result:Further showed anti-angiogenic effect in vivo, inhibited ocular neovascularization.
体外研究：
DCZ19931 (1 nM-10 μM; 24 h) 对人脐静脉内皮细胞 (HUVECs) 无明显的细胞毒性。DCZ19931 (500 nM; 24 h) 抑制 (10 ng/mL; 12 h) VEGFs 诱导的内皮细胞增殖、迁移和成管能力。DCZ19931 (500 nM; 24 h) 通过下调 ICAM-1，表达抑制血管通透性。DCZ19931 (500 nM; 24 h) 降低 HUVECs 中 p-ERK1/2、p-p38 和 p-JNK 的表达水平。DCZ19931 在小鼠脉络膜发芽试验中也显示出抗血管生成作用。
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