产品
编 号：F755969
分子式：C30H32N8O4
分子量：568.63
分子式：C30H32N8O4
分子量：568.63
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规格
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结构图
CAS No: 2775446-64-3
产品详情
生物活性：
Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis.
体外研究：
Top/HDAC-IN-2 (45b) shows antitumor activities against the HCT116 (IC50 = 0.23 μM), MCF-7 and A549 cells.Top/HDAC-IN-2 (45b) (0-5 μM, 24h) arrests the HCT116 cell cycle at the G2 phase in a concentration-dependent manner.Top/HDAC-IN-2 (45b) (0-2.5 μM, 24h) induces the apoptosis in HCT116 cell line in a concentration-dependent manner.Top/HDAC-IN-2 (45b) (0-5 μM, 24h) inhibits HDAC in living cells.
Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis.
体外研究：
Top/HDAC-IN-2 (45b) shows antitumor activities against the HCT116 (IC50 = 0.23 μM), MCF-7 and A549 cells.Top/HDAC-IN-2 (45b) (0-5 μM, 24h) arrests the HCT116 cell cycle at the G2 phase in a concentration-dependent manner.Top/HDAC-IN-2 (45b) (0-2.5 μM, 24h) induces the apoptosis in HCT116 cell line in a concentration-dependent manner.Top/HDAC-IN-2 (45b) (0-5 μM, 24h) inhibits HDAC in living cells.
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