产品
编 号：F755942
分子式：C26H43NO3
分子量：417.62
分子式：C26H43NO3
分子量：417.62
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CAS No: 2772379-97-0
产品详情
生物活性：
CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity.
体内研究：
CB1/2 agonist 2 (compound 23) (0-6 mg/kg, IP, once) significantly reduces the late phase of formalin-induced nocifensive behaviour at 6 mg/kg.Animal Model:Male CD-1 outbred mice (40-45 g)
Dosage:0, 1, 3, and 6 mg/kg
Administration:IP, once, 10 min before the formalin or saline injection
Result:Significantly reduced the late phase of formalin-induced nocifensive behaviour at the highest dose (6 mg/kg, i.p.), whereas no effect was produced by doses of 1 and 3 mg/kg.
体外研究：
CB1/2 agonist 2 (compound 23) (1 μM, 24-72 h) exhibits a very low cytotoxic potential in Hep-G2 cells. CB1/2 agonist 2 (0-10 μM) shows a slight but significant inhibition of [35S]GTPγS binding to hCB2-CHO cell membranes, with a mean EC50 of 397.90 nM and a mean Emax value of -17.81%.
CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity.
体内研究：
CB1/2 agonist 2 (compound 23) (0-6 mg/kg, IP, once) significantly reduces the late phase of formalin-induced nocifensive behaviour at 6 mg/kg.Animal Model:Male CD-1 outbred mice (40-45 g)
Dosage:0, 1, 3, and 6 mg/kg
Administration:IP, once, 10 min before the formalin or saline injection
Result:Significantly reduced the late phase of formalin-induced nocifensive behaviour at the highest dose (6 mg/kg, i.p.), whereas no effect was produced by doses of 1 and 3 mg/kg.
体外研究：
CB1/2 agonist 2 (compound 23) (1 μM, 24-72 h) exhibits a very low cytotoxic potential in Hep-G2 cells. CB1/2 agonist 2 (0-10 μM) shows a slight but significant inhibition of [35S]GTPγS binding to hCB2-CHO cell membranes, with a mean EC50 of 397.90 nM and a mean Emax value of -17.81%.
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