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编 号：F755885
分子式：C16H19N2NaO5S
分子量：374.39
分子式：C16H19N2NaO5S
分子量：374.39
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CAS No: 2768759-64-2
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生物活性：
NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout.
体内研究：
NLRP3-IN-9 (3, 10 mg/kg; i.p.) 减少急性痛风小鼠模型中的炎症和机械痛觉。Animal Model:3-4 month old male and female C57BL/6J WT and NLRP3-KO mice
Dosage:3, 10 mg/kg
Administration:I.p.
Result:Reduced paw swelling by 40% in males and 33% in females at 3 mg/kg, and 66% in males and 52% in females at 10 mg/kg in WT mouse.
体外研究：
NLRP3-IN-9 (compound 4b) (0.01-3 μM) 在 ATP (5 mM) 和 LPS (1 μg/mL) 诱导的巨噬细胞中以剂量依赖性方式抑制 IL-1β 释放.NLRP3-IN-9 (1 μM; 15 min) 抑制 NLRP3 炎性体寡聚化。
NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout.
体内研究：
NLRP3-IN-9 (3, 10 mg/kg; i.p.) 减少急性痛风小鼠模型中的炎症和机械痛觉。Animal Model:3-4 month old male and female C57BL/6J WT and NLRP3-KO mice
Dosage:3, 10 mg/kg
Administration:I.p.
Result:Reduced paw swelling by 40% in males and 33% in females at 3 mg/kg, and 66% in males and 52% in females at 10 mg/kg in WT mouse.
体外研究：
NLRP3-IN-9 (compound 4b) (0.01-3 μM) 在 ATP (5 mM) 和 LPS (1 μg/mL) 诱导的巨噬细胞中以剂量依赖性方式抑制 IL-1β 释放.NLRP3-IN-9 (1 μM; 15 min) 抑制 NLRP3 炎性体寡聚化。
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