产品
编 号：F755857
分子式：C20H17F5N2O2
分子量：412.35
分子式：C20H17F5N2O2
分子量：412.35
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CAS No: 2768139-73-5
产品详情
生物活性：
(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1).
体内研究：
(Rac)-ErSO-DFP (compound 2) (5 mg/kg; i.v.; 3xq.wk.) shows a sustained activity of againsting ERα+ breast cancer at low doses.Animal Model:Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model).
Dosage:5 mg/kg
Administration:Intravenous injection; once-a-week for 3 total doses.
Result:Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer.
体外研究：
(Rac)-ErSO-DFP (compound 2) (0.001-1 μM; 24 h) maintains potent anticancer activity with IC50 of 35 nM in MCF-7 cells.
(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1).
体内研究：
(Rac)-ErSO-DFP (compound 2) (5 mg/kg; i.v.; 3xq.wk.) shows a sustained activity of againsting ERα+ breast cancer at low doses.Animal Model:Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model).
Dosage:5 mg/kg
Administration:Intravenous injection; once-a-week for 3 total doses.
Result:Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer.
体外研究：
(Rac)-ErSO-DFP (compound 2) (0.001-1 μM; 24 h) maintains potent anticancer activity with IC50 of 35 nM in MCF-7 cells.
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