产品
编 号：F755850
分子式：C33H26BrN5O2
分子量：604.5
分子式：C33H26BrN5O2
分子量：604.5
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CAS No: 2768011-36-3
产品详情
生物活性：
SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.
体外研究：
SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively.SP-471P (10 μM; 48 hours) exhibits an EC50 value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells.SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2.SP-471P (10 μM; 30 hours) targets the NS3int cleavage site of DENV in DENV2-infected Huh7 cells.
SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.
体外研究：
SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively.SP-471P (10 μM; 48 hours) exhibits an EC50 value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells.SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2.SP-471P (10 μM; 30 hours) targets the NS3int cleavage site of DENV in DENV2-infected Huh7 cells.
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