产品
编 号：F755845
分子式：C23H26N6O4
分子量：450.49
分子式：C23H26N6O4
分子量：450.49
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CAS No: 2767560-94-9
产品详情
生物活性：
A2AAR/HDAC-IN-2 is a potent A2AAR/HDAC dual inhibitor, with good binding affinity for A2AAR (Ki=10.3 nM) and good inhibitory activity against HDAC1 (IC50=18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor.
体外研究：
A2AAR/HDAC-IN-2 (compound 30c) (5 nM-100 μM; 72 h) shows anti-proliferative activity, with GI50s of 12.16 and 12.61 μM for CT26 and MC38 cells, respectively.A2AAR/HDAC-IN-2 (0.1, 1, 5, 10 μM; 24 h) increases histone H3 and H4 acetylation in a concentration-dependent manner in MC38 cells.
A2AAR/HDAC-IN-2 is a potent A2AAR/HDAC dual inhibitor, with good binding affinity for A2AAR (Ki=10.3 nM) and good inhibitory activity against HDAC1 (IC50=18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor.
体外研究：
A2AAR/HDAC-IN-2 (compound 30c) (5 nM-100 μM; 72 h) shows anti-proliferative activity, with GI50s of 12.16 and 12.61 μM for CT26 and MC38 cells, respectively.A2AAR/HDAC-IN-2 (0.1, 1, 5, 10 μM; 24 h) increases histone H3 and H4 acetylation in a concentration-dependent manner in MC38 cells.
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