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编 号:F755835
分子式:C41H52N6O6S2
分子量:789.02
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally?bioavailable and selective AR-V7 degrader with the DC50?of 0.32?μM by recruiting VHL E3?ligase?to Androgen receptor?(AR) DNA binding?domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 μM.
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