产品
编 号:F755815
分子式:C21H25N3O3
分子量:367.44
产品类型
结构图
CAS No: 2766688-19-9
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产品详情
生物活性:
HDAC-IN-33 is a potent HDAC inhibitor with IC50s of 24, 46, and 47 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-33 possesses potent antiproliferation activities against tumor cells. HDAC-IN-33 shows potent antitumor efficacy in vivo That trigger antitumor immunity.
体外研究:
HDAC-IN-33 (Compound 9l)?shows good in vivo antitumor efficacies in both HEL xenograft model and murine melanoma model. HDAC-IN-33 promotes the antigen presentation and activate T cells, thereby triggering antitumor immunity.