产品
编 号：F755814
分子式：C20H23N3O3
分子量：353.41
分子式：C20H23N3O3
分子量：353.41
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CAS No: 2766688-17-7
产品详情
生物活性：
HDAC-IN-32 is a potent HDAC inhibitor with IC50s of 5.2, 11, and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 possesses potent antiproliferation activities against tumor cells. HDAC-IN-32 shows potent antitumor efficacy in vivo That trigger antitumor immunity.
体外研究：
HDAC-IN-32 (compound 9k) induces upregulation of Ac-HH3 and Ac-tubulin in tumor cells and induces apoptosis by cleavage of caspase-3. HDAC-IN-32 induces downregulation of SSRP1 and SPT16 and leads to chromatin damage. HDAC-IN-32 possesses better antimigration activities than SAHA and could reduce the expression level of MMP-2, which plays critical roles in tumor migration.
HDAC-IN-32 is a potent HDAC inhibitor with IC50s of 5.2, 11, and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 possesses potent antiproliferation activities against tumor cells. HDAC-IN-32 shows potent antitumor efficacy in vivo That trigger antitumor immunity.
体外研究：
HDAC-IN-32 (compound 9k) induces upregulation of Ac-HH3 and Ac-tubulin in tumor cells and induces apoptosis by cleavage of caspase-3. HDAC-IN-32 induces downregulation of SSRP1 and SPT16 and leads to chromatin damage. HDAC-IN-32 possesses better antimigration activities than SAHA and could reduce the expression level of MMP-2, which plays critical roles in tumor migration.
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